Apr 03, 2025
Coordinated AI agents for advancing healthcare | Nature Biomedical Engineering
Nature Biomedical Engineering (2025)Cite this article 449 Accesses 97 Altmetric Metrics details Decentralized yet coordinated networks of specialized artificial intelligence agents, multi-agent
Nature Biomedical Engineering (2025)Cite this article
449 Accesses
97 Altmetric
Metrics details
Decentralized yet coordinated networks of specialized artificial intelligence agents, multi-agent systems for healthcare (MASH), that excel in performing tasks in an assistive or autonomous manner within specific clinical and operational domains are likely to become the next paradigm in medical artificial intelligence.
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Li, J., Zhang, Q., Yu, Y., Fu, Q. & Ye, D. Trans. Mach. Learn. Res. https://openreview.net/forum?id=bgzUSZ8aeg (2024).
Snell, C., Lee, J., Xu, K. & Kumar, A. Preprint at https://arxiv.org/abs/2408.03314 (2024).
Learning to reason with LLMs (OpenAI, 2024); https://openai.com/index/learning-to-reason-with-llms
Akyürek, E. et al. Preprint at https://arxiv.org/abs/2411.07279 (2024).
Agashe, S., Fan, Y., Reyna, A. & Wang, X. E. Preprint at https://arxiv.org/abs/2310.03903 (2024).
Kim, Y. et al. Preprint at https://arxiv.org/abs/2404.15155 (2024).
Mukherjee, S. et al. Preprint at https://arxiv.org/abs/2403.13313 (2024).
Sun, G. et al. Preprint at https://arxiv.org/html/2210.01708v3 (2024).
Du, Y., Li, S., Torralba, A., Tenenbaum, J. B. & Mordatch, I. Preprint at https://arxiv.org/abs/2305.14325 (2023).
Lee, P., Bubeck, S. & Petro, J. N. Engl. J. Med. 388, 1233–1239 (2023).
PubMed Google Scholar
Heiman, A. et al. Preprint at https://arxiv.org/abs/2411.18672 (2024).
Johri, S. et al. Nat. Med. 31, 77–86 (2025).
CAS PubMed Google Scholar
Jha, A. K. et al. A Crisis in Health Care: a Call to Action on Physician Burnout (Massachusetts Medical Society, Massachusetts Health and Hospital Association, Harvard T.H. Chan School of Public Health & Harvard Global Health Institute, 2019); https://go.nature.com/4gAwfA2
Meskó, B. & Topol, E. J. npj Digit. Med. 6, 120 (2023).
PubMed PubMed Central Google Scholar
Yao, S., Shinn, N., Razavi, P. & Narasimhan, K. Preprint at https://arxiv.org/abs/2406.12045v1 (2024).
Schmidgall, S. et al. Preprint at https://arxiv.org/abs/2405.07960v3 (2024).
Topol, E. J. Lancet 402, 1411 (2023).
PubMed Google Scholar
Tu, T. et al. Preprint at https://arxiv.org/abs/2401.05654 (2024).
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We thank R. Reddy for early review and discussion of the figures.
Saint Louis University, SSM Health, St. Louis, MO, USA
Michael Moritz
Scripps Research, La Jolla, CA, USA
Eric Topol
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Pranav Rajpurkar
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M.M., E.T. and P.R. all contributed to the design, drafting and editing of the manuscript.
Correspondence to Pranav Rajpurkar.
The authors declare no competing interests.
Nature Biomedical Engineering thanks Ahmed Alaa and Vivek Natarajan for their contribution to the peer review of this work.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Moritz, M., Topol, E. & Rajpurkar, P. Coordinated AI agents for advancing healthcare. Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01363-2
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Published: 01 April 2025
DOI: https://doi.org/10.1038/s41551-025-01363-2
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